Rebuilding Collagen: The Key to Prolotherapy Part 3

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Liu’s study (1)confirmed the results of an earlier study done by George Hackett (2), M.D. In 1955, Dr. Hackett and his colleague Dr. D.G. Henderson, reported on two years experimentation on the effects of the proliferant Sylnasol when injected into rabbit tendons.

In 48 hours, histological tissue examinations revealed an early inflammatory reaction surrounding the nerves and blood vessels with lymphocytic (immune system cells that remove damaged tissue) infiltration throughout the area between the two tendons and between the tendons and its sheath.

Two weeks after the injection, fibrous tissue was present; lymphocytic infiltration had diminished, although some was still present, which showed that the proliferation of new white fibrous tissue was still being stimulated.

One month after injection, fibrous tissue was present, and lymphocytic and fibroblastic (immune system rebuilding cells) activity was greatly diminished. In other words, they finished their jobs and moved on.

One year after three injections of the proliferant solution, the diameter of the tendons increased dramatically, which was estimated to double the strength of the tendon.

References

1. Liu Y, Tipton C, Matthes R, Bedford T, Maynard J, Walmer H. An in situ study of the influence of a sclerosing solution in rabbit medial collateral ligaments and its junction strength. Connect Tissue Res 1983;11:95-102.

2. Hackett GS, Henderson DG. Joint Stabilization: An experimental, histologic study with comments on the clinical application in ligament proliferation. Amer J Surg 1955;89:968-1973.